Building scars for integrable systems

It is shown, by means of a simple specific example, that for integrable systems it is possible to build up approximate eigenfunctions, called {\it asymptotic eigenfunctions}, which are concentrated as much as one wants to a classical trajectory and have a lifetime as long as one wants. These states are directly related to the presence of shell structures in the quantal spectrum of the system. It is argued that the result can be extended to classically chaotic system, at least in the asymptotic regime

The Educational Adjustment Program Profile: A Queensland Initiative in the identification and Monitoring of Students with a Disability

The effective identification and monitoring of students with a disability is a complex and important aspect of educational service delivery for students with a disability in Queensland. Building on previous initiatives in this domain Education Queensland has piloted the development of the Educational Adjustment Program (EAP) profile. Based on the data from the initial survey sample of more than 1500 school age students with a disability across Queensland, this paper highlights: the design of the Education Adjustment Program Adjustment Profile (EAP); some of its psychometric properties; gender and Indigenous student dimensions within the data; and how the EAP instrument compares with the 1 to 6 ascertainment rating scale

Micro-universes and "strong black holes": a purely geometric approach to elementary particles

We present here a panoramic view of our unified, bi--scale theory of gravitational and strong interactions [which is mathematically analogous to the last version of N.Rosen's bi--metric theory; and yields physical results similar to strong gravity's]. This theory, developed during the last 15 years, is purely geometrical in nature, adopting the methods of General Relativity for the description of hadron structure and strong interactions. In particular, hadrons are associated with `` strong black--holes'', from the external point of view, and with ``micro--universes'', from the internal point of view. Among the results herein presented, let us mention the derivation: (i) of confinement and (ii) asymptotic freedom for the hadron constituents; (iii) of the Yukawa behaviour for the strong potential at the static limit; (iv) of the strong coupling ``constant'', and (v) of mesonic mass spectra

Quaternion methods for random matrices in quantum physics

The theory of random matrices, or random matrix theory, RMT in what follows, has been developed at the beginning of the fties to describe the sta- tistical properties of energy levels of complex quantum systems, [1], [2], [3]. In the early eighties it has enjoyed renewed interest since it has been recognized as a very useful tool in the study of numerous physical systems. Specically, it is very useful in the analysis of chaotic quantum systems. In fact, in the last years many papers appeared about the problem of quantum chaos which implies the quantization of systems whose underlying classical dynamics is irregular (i.e. chaotic). The simplest models considered in this eld are billi- ards of various shapes. From the the classical point of view, a point particle in a 2-dimensional billiard displays regular or irregular motion depending on the shape of the billiard; for instance motion in a rectangular or circular billi- ard is regular thanks to the symmetries of the boundary. On the other hand, billiards of arbitrary shapes imply chaotic motion, i.e. exponential diver- gence of initially nearby trajectories. In order to study quantum billiards we have to consider the Schroedinger equation in various 2-dimensional domains. The eigenvalues of the Schroedinger equation represent the allowed energy levels of our quantum particle in the billiard under consideration, while the eigenfunction norms represent the probability density of nding the particle in a certain position. The question of quantum chaos is whether the charac- ter of the classical motion (regular or chaotic) can in uence some propertie

Identification of Flexural Rigidity in a Kirchhoff Plates Model Using a Convex Objective and Continuous Newton Method

This work provides a detailed theoretical and numerical study of the inverse problem of identifying flexural rigidity in Kirchhoff plate models. From a mathematical standpoint, this inverse problem requires estimating a variable coefficient in a fourth-order boundary value problem.This inverse problem and related estimation problems associated with general plates and shellmodels have been investigated by numerous researchers through an optimization framework using the output least-squares (OLSs) formulation. OLS yields a nonconvex framework and hence it is suitable for investigating only the local behavior of the solution. In this work, we propose a new convex framework for the inverse problem of identifying a variable parameter in a fourth-order inverse problem. Existence results, optimality conditions, and discretization issues are discussed in detail. The discrete inverse problem is solved by using a continuous Newton method. Numerical results show the feasibility of the proposed framework

18 Ne diproton decay

Two proton radioactivity studies have been performed on excited states of 18 Ne produced, among other fragments, by 20 Ne projectile fragmentation and excited via Coulomb excitation on a Pb target. Every incoming ion was tagged before interacting with the lead target on an event by event basis in order to discriminate the secondary reactions according to the projectile. Decay of 18 Ne levels has been studied by complete kinematical reconstruction. In spite of the low statistics a couple of events looks very promising for two proton correlated emission

First experimental evidence of 2He decay from 18Ne excited states

Two-proton decay from 18Ne excited states has been studied by complete kinematical detection of the decay products. The 18Ne nucleus has been produced as a radioactive beam by 20Ne projectile fragmentation at 45 AMeV on a 9Be target, using the FRIBs in-flight facility of the LNS. The 18Ne at 33 AMeV incident energy has been excited via Coulomb excitation on a natPb target. The correlated 2p emission has been disentangled from the uncorrelated 2p emission using a high granularity particle detector setup allowing the reconstruction of momentum and angle correlations of the two emitted protons. The obtained results unambiguously show that the 6.15 MeV 18Ne state two-proton decay proceeds through 2He emission (31%) and democratic or virtual sequential decay (69%)

Immune-checkpoint inhibitors from cancer to COVID‑19: A promising avenue for the treatment of patients with COVID‑19

The severe acute respiratory syndrome associated coronavirus‑2 (SARS‑CoV‑2) poses a threat to human life worldwide. Since early March, 2020, coronavirus disease 2019 (COVID‑19), characterized by an acute and often severe form of pneumonia, has been declared a pandemic. This has led to a boom in biomedical research studies at all stages of the pipeline, from the in vitro to the clinical phase. In line with this global effort, known drugs, currently used for the treatment of other pathologies, including antivirals, immunomodulating compounds and antibodies, are currently used off‑label for the treatment of COVID‑19, in association with the supportive standard care. Yet, no effective treatments have been identified. A new hope stems from medical oncology and relies on the use of immune‑checkpoint inhibitors (ICIs). In particular, amongst the ICIs, antibodies able to block the programmed death‑1 (PD‑1)/PD ligand-1 (PD‑L1) pathway have revealed a hidden potential. In fact, patients with severe and critical COVID‑19, even prior to the appearance of acute respiratory distress syndrome, exhibit lymphocytopenia and suffer from T‑cell exhaustion, which may lead to viral sepsis and an increased mortality rate. It has been observed that cancer patients, who usually are immunocompromised, may restore their anti‑tumoral immune response when treated with ICIs. Moreover, viral-infected mice and humans, exhibit a T‑cell exhaustion, which is also observed following SARS‑CoV‑2 infection. Importantly, when treated with anti‑PD‑1 and anti‑PD‑L1 antibodies, they restore their T‑cell competence and efficiently counteract the viral infection. Based on these observations, four clinical trials are currently open, to examine the efficacy of anti‑PD‑1 antibody administration to both cancer and non‑cancer individuals affected by COVID‑19. The results may prove the hypothesis that restoring exhausted T‑cells may be a winning strategy to beat SARS‑CoV‑2 infection